Wisdom in treatment of our adrenals
The following represents adrenal gems in patient-reported experiences and wisdom concerning their adrenals and issues. especially adrenal fatigue. But remember: this is just information and is not to replace your relationship or guidance with your doctor. See the Disclaimer.
1) Patients have learned it is never wise to guess whether we have low cortisol, even if we “think” you do!
With our adrenals, some symptoms of high cortisol can be similar to symptoms of low cortisol, patients noted repeatedly. So we could end up treating the wrong thing. Plus there are different variations of an adrenal problem which require different treatments–see below.
2) The 4-point saliva cortisol is the best way to find out for most hypo patients, NOT blood testing, patients discovered.
Blood testing is measuring the combination of bound and unbound cortisol, of which 80% or higher is bound. So patients saw they could look high when they were actually low, cellularly. This has happened to a lot of patients!
Saliva will test you at four key times in a 24 hour period, and measures your cellular levels, which is key. There is a 6-point test, but it’s not only more expensive, but not needed for most! They even knew saliva was the way to go in 1983! Here’s an example of a good self-ordered saliva test.
Note: we avoid the QUEST saliva test to test adrenals. It gives the ranges as “less than” or “more than” a particular number–useless for interpretation.
Remember not to eat right before any of your four saliva vial spits. Eating will either push cortisol too high, or if you already have low cortisol, can stress the adrenals even more.)
3) Treatment for adrenals should be based on saliva testing that is no more than three months old, as learned the hard way by thyroid patients.
Patients report learning the hard way that cortisol levels can change. So what was true three or more months ago, may not be the same now (even though it will be problematic), so you’d be treating the wrong thing today that was true then.
4) Saliva results have nothing to do with falling in the normal range, patients observed!
Patients discovered, upon viewing the saliva results of many others who did not have a cortisol problem, that the results have to do with “where” they fall in ranges. See where folks fall when their cortisol levels are ideal here.
DIFFERENT KINDS OF ADRENAL ISSUES AS REVEALED BY SALIVA TESTING…and how we learned to treat them
1) High cortisol:
High cortisol results are defined as “two or more results together which are too high”. Examples include high morning and high noon….or high afternoon and high bedtime. Often the others are close to where they should be or too low. But in the early stage of adrenal problems, all could be high.
Excessive progesterone supplementation has caused high cortisol in some women, but so can other issues like continued hypothyroidism, excess stress, active Lyme disease, etc. High cortisol can block the conversion of T4 to T3, favoring conversion to RT3 and putting you further into a hypothyroid state. See the RT3 information in the revised STTM book for more info, as well.
***Read the last chapter of the STTM II book which does an EXCELLENT job explaining why our cortisol first goes high…then why it can fall to low, by Dr. Laura Stone, MD. A highly recommended chapter!!
TREATMENT: Patients report using certain supplements like Holy Basil, zinc, Phosphatidylserine, etc to help lower the high results while correcting what was causing it. The latter is important. In turn, by lowering high cortisol, the other low cortisol results (if you have some lows) can come up a bit, though sometimes patients choose to use a cortisol supplement for a short time during those low times. The former supplements are not for long term and each person should look them up to make sure there’s nothing in any that would be a problem for them. Work with your doctor.
2) A see-saw mix of highs and lows:
Picture up, down, up, down or vice-versa. An example is a morning result far over the range, very low noon result, overly high afternoon result. Picture a see-saw, which is different than having two highs in a row. This see-saw pattern is more the pattern of healthy adrenal function but one that is reacting to stress.
Both high cortisol and low cortisol can cause problems raising Natural Desiccated Thyroid or T3, first causing hyper-like symptoms from excess adrenaline, then causing too much RT3.
TREATMENT: Since this see-saw result is simply a stress pattern of healthy adrenal function, patients use certain adaptogens at least three times a day which help even out your body’s response to stress, both raising low and lowering high. Examples include Ashwagandha, Rhodiola, Relora, Eleuthero, Maca, Schisandra, etc. Patients will often combine them, or take alone. Patients also state they usually need more than the recommended dose on a bottle. Janie keeps these on hand to use if she’s going through prolonged stress. Many are described in Chapter 15 of the revised STTM book. Also see pages 106 – 108 in the revised STTM book.
3) Low Cortisol
Low Cortisol can happen with one low, two or three lows, or all four lows on saliva. This is where the term “adrenal fatigue” comes into play, though it could also be called adrenal insufficiency or hypocortisolism (See the excellent Chapter 15 in the STTM II book–a highly recommended chapter by a practitioner!)
TREATMENT: This is where you need to study chapters 5 and 6 of the updated revision STTM book as to whether to use ACE (Adrenal Cortex) or HC (prescription hydrocortisone). Chapter 6 also explains HOW we dose them, the Daily Average Temps, about stress dosing and more.
Cortisol is needed to allow T3 to enter our cells and to finally allow us to get out of our hypothyroid state–the latter a strong reason many have adrenal issues in the first place.
Low cortisol is not treated as well with adaptogens, patients report. Adaptogens work far better with the stress response of healthy adrenal function, such as high, low, high, low or vice versa on a saliva test. Yes, some report they feel a bit better having very low cortisol and using adaptogens….but they continue to have that low cortisol, which will prevent you from getting out of your hypothyroid state.
POINTS OF INTEREST
1) Licorice Root (If you have slightly low cortisol at “one” particular time–this is not for those who have several times of low cortisol or seriously low cortisol)
Licorice root, with its glycyrrhizin content, is used to make slightly low cortisol more useable i.e. it prevents your liver from breaking down cortisol as much. Capsules or tea is used. It can’t be used long term, as it tends to raise blood pressure in some folks because it lowers potassium. But short term use has worked well for many. Or taking potassium at the same time might work.
2) Avoiding “Adrenal glandular” products
“Adrenal glandulars” are NOT the same as “Adrenal cortex”. Glandulars give you the entire gland, and know why that can be a problem?? Adrenal glandulars are BOTH the medulla and cortex. The cortex contains cortisol, yes, but the medulla contains adrenaline. Oops. If you have an adrenal problem, you most likely already make too much.
EXCEPTION: Thorne’s Adrenal Cortex (to the right) added “Adrenal glandular” underneath Adrenal Cortex. Yes, the cortex is part of the “gland”, but in this case, it is NOT what products call adrenal glandular. So you are fine with what you see to the right.
3) Using Hydrocortisone when three or more times are seriously low
It’s extremely important to study Chapter 6 in the updated revised STTM book about what patients report learning in their successful use of HC. Find a good doctor to work with on all this! The chapter also applies to what patients learned with ACE (adrenal cortex). Patients report using Daily Average Temp taking (DATs) to find the right amount, since this is not about high pharmacological amounts of cortisol. Knowing about stress dosing is also very important. It’s important to watch your sex hormones and calcium levels while on HC, as they can dive, some patients have noted. HC or ACE use is short-term–long enough to correct all the issues which stress the adrenals, then a wean. It’s not like the protocol used for Addison’s or a permanent pituitary problem. Please share this information in working with your doctor.
4) The T3 Circadian Method aka CT3M
This is an ideal method if you just have low morning cortisol. This is a very safe protocol, and when done correctly, avoids the use of any of the above (though adaptogens can be used with it during the day, and some patients are using cortex or HC, and helps bring back better cortisol levels. Good detailed summary here. Many patients have found it isn’t enough if they also have low cortisol in the afternoon, or have seriously low cortisol all day. i.e it works for some, not for others
MISTAKES PATIENTS MAKE WITH THEIR ADRENALS
- Failing to do saliva testing: read all four points under TESTING above. Patients have repeatedly found it unwise to guess, or to even go by older saliva results. Blood cortisol has been a failure since it’s measuring both bound and unbound and implies you are okay or high when you are not.
- Using ACE or glandular when they didn’t need it: common when someone didn’t do saliva testing and is guessing. Or, if saliva does prove low cortisol, it’s too low for any of these to do the job well.
- Using Adrenal Glandulars for low cortisol when one already makes too much adrenaline: Unless stated otherwise, glandulars contains adrenaline, and if a patient has found themselves with hyper-like symptoms–higher heartrate, palps, anxiety–glandulars can end up contributing because of their adrenaline content!
- Using the CT3M when your levels are seriously low: the CT3M by itself works better for just low morning for most. There are some who got no results at noon, and definitely many who saw no improvement in the afternoon. There are others who got great improvements. So it’s up to you!
- Failing to do their Daily Average Temps when using ACE or HC: This is a huge mistake, patients report, resulting is staying on too low a dose, or going too high. See The Temperature Test on page 82 of revised STTM book.
MISTAKES PATIENTS MAKE IN THEIR USE OF HYDROCORTISONE (HC) or ADRENAL CORTEX
To read more about adrenals, go here.
If you suspect other causes of low cortisol, go here.
To order the revised STTM book with its two excellent chapters on adrenals, go here. Though Chapter 6 in the revised STTM books refers to HC/hydrocortisone/Cortef, all the principles apply to Adrenal Cortex supplements. Read, read, read! Your knowledge is important in working with your doctor.
**Interesting information about your Circadian Rhythm: Cortisol levels reach lowest levels at around midnight, levels start to rise at around 02:00 to 03:00 and reach a peak at around 08:30 am. Cortisol levels then slowly decrease back to the nadir to complete the cycle over 24 hours. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3475279/
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