NOTE that if you have diabetes or insulin resistance, you’ll need to treat those issues to make this protocol work right, since correct insulin response is needed. If you have hypopituitary or Addisons, you’ll need HC instead.


1) Why can’t we use time-released T3?

From Paul: Slow-release T3 prevents the large peaks of cellular T3 that some people actually need to overcome what I call ‘impaired cellular response to thyroid hormone’. Some people just do not respond well to normal blood levels of thyroid hormones. My book outlines several medically validated reasons why this can occur (even though the doctors are lightyears behind on this – the researchers are not). In order to overcome these then enough peak cellular T3 needs to be reached. In my book ‘Recovering with T3’ I liken this to a wave of T3 that has to reach the interior of the cells. A small wave is only able to throw the foamy top of the wave onto the targets in the cells. A much larger wave will dump a large amount of the wave onto the targets within the cells. Slow release T3 is incapable of being fin-tuned to deliver a big enough wave – it is fundamentally a poor tool for the treatment of ‘impaired cellular response to thyroid hormone’.

2) Exactly what do patients notice in the data (BP, pulse, and temp after waking up) when they feel they have found their correct T3CM dosing time?

Normal BP (rises to normal usually), pulse (usually comes down to normal), temp (rises to normal usually), and one feels much better when waking up, ready to face the day. More importantly energy levels and sense of well being usually floods into the body.

3) What if someone’s sleep schedule is messed up due to the adrenal/thyroid mess? i.e. they are waking up at 10 am instead of their normal 8 am? Do they look at a four hour window with the messed up schedule, or the previous normal 8 am wakeup?

Trial and error. Make best guess and then slowly titrate the dose in time and size. The results help to tell you what’s going on.

4) For those who end up staying on HC when doing the T3 circadian protocol (because it’s too miserable to wean down and takes too long to do it safely), would they notice a raise in BP/temp when their adrenals pick up?

From Paul: I’d want some reduction in HC because what is the point of attempting this otherwise and how would you know it was working? If the adrenals don’t need to work any harder because the HC is making up the difference then providing extra T3 won’t do much if the pituitary doesn’t want to ask the adrenals to do something. If BP was still low and temp was still low because even with the HC the adrenals a re still struggling then I’d expect to see some improvements in signs like these and a general sense of well being and energy. You have to feel your way but it would be important to only use a small early T3 dose (10-20 mcg) to avoid getting a massive surge of cortisol and a bad reaction. This last point applies anyway.

5) Which part of the HC I’m on should I drop first when I note the T3CM is working?

The morning, but not drop at first. Instead, move later and later while dropping it down. It will end up defeating your new cortisol production for the rest of the day.

6) How long have your adrenals been healed as author?

From Paul: About 3 days after I started to use the early T3 dose. I don’t think my adrenals were ever truly damaged they were just T3 starved. Most adrenal damage is via autoantibodies in Addison’s disease. Sure adrenals can be knocked about, battered and world- weary but that isn’t the kind of destruction present in Addison’s. I haven’t used any adrenal support for nearly 15 years. Some peoples’ adrenals may be damaged, of course, and they may always need some level of adrenal support

7) Do you still use the T3 in the early morning hours?

From Paul: I used to.  Thought I couldn’t manage without. Today, I’ve been able to be without it.

8) What do you feel has been the most difficult part for you with using T3-only?

From Paul: Depends what you compare it with. Nothing else works for me due to my strange reactions to T4, so it’s not difficult compared to being sick. I guess when things change then the T3 needs to be adjusted. Over time my thyroid has been totally destroyed, my autoantibodies have dropped to zero and my adrenals have recovered. Once I found a good dosage I have every few years had to adjust it slightly to account for internal changes like this – but nothing has been really difficult once I understood what was going on

9) Does the above protocol work with the use of Natural Desiccated Thyroid? Yes!! It’s got direct T3, as well. Some may need T3-only though due to excess RT3 on the cell receptors.

10) What about the use of T3 at bedtime? Yes, it appears this also promotes better adrenal function in some, since the T3 is still around when that four-hour window starts. So some people are doing both—giving themselves T3 at  bedtime, plus in the early morning hours.

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