The following is information Janie put together to help her remember it all…and might be helpful for you!  All too frequently, people with mold illness just might be getting the wrong diagnosis like CFS/ME. 

1) Mold illness is CIRS (Chronic Inflammatory Response Syndrome) i.e systemic inflammation that doesn’t go away. They are one and the same for a lot of people (even if a small % with mold illness may not have CIRS). More about CIRS here: http://www.survivingmold.com/docs/Berndtson_essay_2_CIRS.pdf

2) Mold illness/CIRS can be caused by the HLA-DR gene mutation when one is exposed to mold or mold spores, i.e. your body is unable to make the needed antibodies to deactivate/remove mold. 25% of people have this problem.

3) Because the biotoxins can’t get out of your body, your internal defenses (inflammation) never turn off–the hamster on the wheel.

4) Along with the “I’m stayin’ here” mold, chronic inflammation causes all sorts of problems in the body, including fatigue. More seriously down the line, chronic inflammation can possibly lead to alzheimer’s, cancer, digestive issues, depression, pain, thyroid problems, cancer and more. The symptoms of Mold Illness/CIRS can be similar to other conditions, thus misdiagnoses like Chronic Fatigue Syndrome or ME.

5) Tests which are important for diagnosis and baseline (in no particular order):

  1. MSH (below 35, inflammation goes up)
  2. HLA DRB/DQB Panel (gene to discern inability to get rid of biotoxin)
  3. MMP-9 (inflammatory marker–should be low 300’s)
  4. C3a and C4a (common for mold alone is good C3a and high C4a)
  5. Vasoactive Intestinal Polypeptide (VIP) (proteins which can cause inflammation and negatively affect the hypothalamus in brain)
  6. Transforming Growth Factor (TGF) beta (polypeptide and cytokine which goes up because of mold; can increase inflammation)
  7. ADH/Arginine Vasopressin (can cause dehydration, frequent urination if problematic)
  8. VEGF (signal protein that can go too low with biotoxins; reduced oxygenation; inhibiting cell growth)
  9. RT3 (inactive thyroid hormone which can go up due to biotoxin inflammation).
  10. VCS test--shows results of brain inflammation

More info here: http://www.survivingmold.com/diagnosis/lab-tests  

6) Good supplement strategies to counter the inflammation, as recommended on the following website: http://www.herbaltransitions.com/TreatmentOfCIRS.html  Avoiding sugar and grains to keep insulin down is also important–the no amylase diet. (I, Janie, used a lot of these recommendations!) In the meantime, binders are needed to get the mold out, such as cholestyramine. 

7) Mold illness/CIRS can activate certain gene mutations, or turn off other genes.

8) Low VEGF (see above in #5) can cause “capillary hypoperfusion”, aka reduced delivery of oxygen leading to reduced mitochondrial function (easy fatigue; easy crashes; long recovery) and a rise of lactic acid. 

9) There are controlled exercises to increase adiponectin which will help with capillary hypoperfusion, explained by Dr. Shoemaker:  https://www.youtube.com/watch?v=jjEDcBbpS_0

10) Dr. Shoemaker developed important steps to get well again. Some can be done at the same time: http://www.survivingmold.com/treatment/step-by-step  He also does phone consultations.

11) Some tests should be repeated in the get-well-again journey to gauge progress: VCS vision test, MSH, etc.

12) A MARCoNS nasal test can be important. MARCoNS represent a staph infection deep in the nose of 80% of those with a low MSH. The staph is antibiotic resistant. http://www.microbiologydx.com/ or www.dlmlabs.com BEG spray is used to treat; can cause nose irritation, fatigue, etc in some. 2-3 sprays a day, 30 days.

13) Some will need VIP spray to raise VIP levels or lower high C4a (dramatically helps fatigue if all else fails; four times a day; important to first clear Marcons and remove mold in house to see effect, says Dr. Shoemaker)

14) Many have gotten well again! Keep the hope!

See: http://www.survivingmold.com/docs/Berndtson_essay_2_CIRS.pdf

See Janie’s story here: https://stopthethyroidmadness.com/mold/

**Dr. Shoemaker does consultation calls. Thank you Dr. Shoemaker for your excellent information which is improving lives!! ~Janie